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| (-)-MK-801 MALEATE Basic information |
| Product Name: | (-)-MK-801 MALEATE | | Synonyms: | (5S,10R)-(-)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE MALEATE;d)cyclohepten-5,10-imine,10,11-dihydro-5-methyl-5h-dibenzo((5s)-5h-dibenzo((z)-2-b;mk801;(-)-MK-801 MALEATE;(+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate;(+)-MK-801 HYDROGEN MALEATE (DIZOCILPINE MALEATE);(5S,10R)-(+)-5-Methyl-10,11-dihydro-(5H)-dibenzo[a.d]cycloheptene-5,10-iminemaleate;Dizocilpine hydrogen maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate | | CAS: | 77086-22-7 | | MF: | C20H19NO4 | | MW: | 337.37 | | EINECS: | 278-614-5 | | Product Categories: | Glutamate;Glutamate receptor;APIs | | Mol File: | 77086-22-7.mol |
| (-)-MK-801 MALEATE Chemical Properties |
| Melting point | 208.5-210° | | alpha | D20 +114° (c = 0.0128 g/2 ml ethanol) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO: >20 mg/mL | | form | solid | | color | white | | optical activity | [α]25/D +117°, c = 1 in methanol(lit.) | | InChIKey | QLTXKCWMEZIHBJ-FWHYOZOBSA-N |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | HP1093575 |
| (-)-MK-801 MALEATE Usage And Synthesis |
| Uses | (-)-MK-801 MALEATE is probe for NMDA receptors
| | Uses | (-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.
| | Uses | Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction. | | General Description | A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures. | | Biological Activity | (-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset™ .
| | Biochem/physiol Actions | Primary TargetNMDA receptor | | references | [1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8. |
| (-)-MK-801 MALEATE Preparation Products And Raw materials |
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