N1-ACETYLSPERMINE TRIHYDROCHLORIDE

CAS No.：77928-70-2

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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N1-ACETYLSPERMINE TRIHYDROCHLORIDE Basic information

Product Name:	N1-ACETYLSPERMINE TRIHYDROCHLORIDE
Synonyms:	N1-ACETYLSPERMINE TRIHYDROCHLORIDE;1-ACETYLSPERMINE TRIHYDROCHLORIDE;N1-Acetylspermine (hydrochloride);N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)acetamide trihydrochloride
CAS:	77928-70-2
MF:	C12H31Cl3N4O
MW:	353.76
EINECS:
Product Categories:
Mol File:	77928-70-2.mol

N1-ACETYLSPERMINE TRIHYDROCHLORIDE Chemical Properties

Melting point	>256°C (dec.)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
BRN	7052482

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

MSDS Information

Provider	Language
SigmaAldrich	English

N1-ACETYLSPERMINE TRIHYDROCHLORIDE Usage And Synthesis

Description

N¹-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower K_m and higher V_max values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. N¹-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.

Uses

N1-Acetylspermine trihydrochloride has been used in a study to determine that the human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.

N1-ACETYLSPERMINE TRIHYDROCHLORIDE Preparation Products And Raw materials

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