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| N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE Basic information | | Description |
| Product Name: | N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE | | Synonyms: | 4-b)indole-3-carboxamide,n-methyl-9h-pyrido(;n-methyl-9h-pyrido(3,4-b)indole-3-carboxamide;FG 7142;N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE;B-carboline-3-carboxylic acid N-*methylamide;N-METHYL-B-CARBOLINE-3-CARBOXAMIDE (FG-7 142);beta-carboline-3-carboxylic acid N-methylamide;β-Carboline-3-carboxylic acid N-methylamide | | CAS: | 78538-74-6 | | MF: | C13H11N3O | | MW: | 225.25 | | EINECS: | | Product Categories: | GABA/Glycine receptor | | Mol File: | 78538-74-6.mol |
| N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE Chemical Properties |
| Boiling point | 576.3±30.0 °C(Predicted) | | density | 1.328±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | ethanol: 1 mg/mL | | pka | 13.44±0.46(Predicted) | | color | light tan |
| WGK Germany | 3 | | RTECS | UU9780100 |
| N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE Usage And Synthesis |
| Description | FG 7142 (ZK 39106; LSU-65) is a nonselective benzodiazepine inverse agonist with high affinity (Ki= 91 nM) for the α1 subunit-containing GABAA receptor. FG 7142 also modulates GABA-induced chloride flux (EC50=137 nM) at GABAA receptors expressing the α1 subunit. FG 7142 increases tyrosine hydroxylation and leads to upregulation of β-adrenergic receptors in mouse cerebral cortex. | | Uses | FG 7142 is a benzodiazepine inverse agonist anxiogenic compound. | | Biological Activity | Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β -adrenoceptors in mouse cerebral cortex. | | Biochem/physiol Actions | Benzodiazepine inverse receptor agonist; potent anxiogenic agent. |
| N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE Preparation Products And Raw materials |
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