Other grades of this product :
| FPG PROTEIN Basic information |
| Product Name: | FPG PROTEIN | | Synonyms: | fpg protein from escherichia coli;DNA-formamidopyrimidine glycosylase;Fpg Protein from Escherichia coli, Recombinant;Fpg Protein from Escherichia coli >=90% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution, >20,000 units/mg protein | | CAS: | 78783-53-6 | | MF: | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| FPG PROTEIN Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 1 |
| FPG PROTEIN Usage And Synthesis |
| Uses | Fpg Protein from Escherichia coli has been used for the assessment of DNA oxidative damage using comet assay. | | General Description | Fpg contains two domains separated by a flexible hinge. | | Biochem/physiol Actions | Fpg is a key enzyme in the DNA base excision repair pathway (BER). It catalyses the excision of a broad spectrum of modified purines. Fpg has both DNA glycosylase activity that removes the mutated base and AP-lyase activity that releases ribose leaving both 5′- and 3′-phosphorylated ends in the DNA. The zinc finger motif at its C-terminus is responsible for the DNA binding and AP-lyase activity. In addition, its N-terminal proline acts as a nucleophile to produce a Schiff base intermediate that is essential for enzyme action. |
| FPG PROTEIN Preparation Products And Raw materials |
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