Other grades of this product :
| Product Name: | D-AP5 | | Synonyms: | D-AP5;D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID;D-2-AMINO-5-PHOSPHONOPENTANOIC ACID;D-(-)-2-AMINO-5-PHOSPHONOVALERIC ACID;D(-)-2-Amino-5-phosphonovaleric acid hydrate;D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID (D-AP5);D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem;D(-)-AP-5, D(-)-APV, D-2-Amino-5-phosphonovaleric acid | | CAS: | 79055-68-8 | | MF: | C5H12NO5P | | MW: | 197.13 | | EINECS: | | Product Categories: | Glutamate;Glutamate receptor | | Mol File: | 79055-68-8.mol |
| D-AP5 Chemical Properties |
| Melting point | approximate 233℃ | | Boiling point | 482.1±55.0 °C(Predicted) | | density | 1.529±0.06 g/cm3(Predicted) | | RTECS | RD2513000 | | storage temp. | Store at RT | | solubility | Soluble to 100 mM in sterile | | form | White solid | | pka | 2.46±0.10(Predicted) | | Sensitive | Light Sensitive |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| D-AP5 Usage And Synthesis |
| Description | D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory. | | Chemical Properties | white fine crystalline powder | | Uses | A competitive NMDA antagonist | | General Description | Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist. | | Biological Activity | Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ . | | Biochem/physiol Actions | Product does not compete with ATP. |
| D-AP5 Preparation Products And Raw materials |
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