Other grades of this product :
| NSC73306 Basic information |
| Product Name: | NSC73306 | | Synonyms: | NSC73306;NSC73306 >=98% (HPLC);(3Z)-1H-Indole-2,3-dione 3-[N-(4-Methoxyphenyl )thiosemicarbazone | | CAS: | 79560-74-0 | | MF: | C16H14N4O2S | | MW: | 326.37 | | EINECS: | | Product Categories: | | Mol File: | 79560-74-0.mol |
| NSC73306 Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | yellow to light brown |
| NSC73306 Usage And Synthesis |
| Uses | (3Z)-1H-Indole-2,3-dione 3-[N-(4-Methoxyphenyl )thiosemicarbazone is a compound involved in the design and synthesis of novel anticancer agents that have the potential to overcome multidrug resistance. | | Biochem/physiol Actions | NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. Irrespective of variations in cell line background, NSC73306 consistently demonstrated a Pgp-potentiated MDR-selective toxicity. It appears that NSC73306 is transported into the cell by copper transporter 1 (CTR1, SLC31A1). It is not P-gp inhibitor. |
| NSC73306 Preparation Products And Raw materials |
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