![1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea](/img/796967-10-7.jpg "1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea")
| 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Basic information |
| Product Name: | 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea |
| Synonyms: | 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea;VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem |
| CAS: | 796967-10-7 |
| MF: | C21H19N5O |
| MW: | 357.41 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 796967-10-7.mol |
| 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Chemical Properties |
| storage temp. | +2C to +8C |
| form | Off-white solid |
| Safety Information |
| MSDS Information |
| 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Usage And Synthesis |
| General Description | A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 μM?h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice). |
| 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Preparation Products And Raw materials |
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