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| IDAZOXAN HYDROCHLORIDE Basic information |
| IDAZOXAN HYDROCHLORIDE Chemical Properties |
| Melting point | 207-208° | | storage temp. | Store at RT | | solubility | H2O: 300 mg/mL |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 7 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 |
| IDAZOXAN HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | mp 207-209°C | | Uses | Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems. | | Uses | An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.
| | Uses | Antiparkinsonian;Alpha2 agonist | | Biological Activity | α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively). | | Biochem/physiol Actions | α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS). |
| IDAZOXAN HYDROCHLORIDE Preparation Products And Raw materials |
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