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| 3,3'-Dithiobis(sulfosuccinimidylpropionate) Basic information |
| Product Name: | 3,3'-Dithiobis(sulfosuccinimidylpropionate) | | Synonyms: | 3,3'-Dithiobis(sulfosuccinimidylpropionate);3,3’-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester 90%;DTSSP 3,3'-Dithiobis(sulfosucciniMidylpropionate);3,3Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester;3,3`-Dithiobis(sulfosucciniMidylpropionate)(DTSSP(Sulfo-DSP));DTSSP Crosslinker;3-Pyrrolidinesulfonic acid, 1,1'-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis[2,5-dioxo-;1,1'-((3,3'-Disulfanediylbis(propanoyl))bis(oxy))bis(2,5-dioxopyrrolidine-3-sulfonic acid) | | CAS: | 81069-02-5 | | MF: | C14H16N2O14S4 | | MW: | 564.54 | | EINECS: | | Product Categories: | Cross Linking Reagents;Homobifunctional Crosslinker | | Mol File: | 81069-02-5.mol |
| 3,3'-Dithiobis(sulfosuccinimidylpropionate) Chemical Properties |
| density | 1.94 | | storage temp. | 2-8°C | | pka | -0.34±0.20(Predicted) |
| Safety Statements | 26-36 | | HS Code | 29309090 |
| 3,3'-Dithiobis(sulfosuccinimidylpropionate) Usage And Synthesis |
| Chemical Properties | 12.0 | | Uses | sulfhydryl reactive cleavable heterobifunctional cross-linking reagent, pyridine-2-thione release can be monitored at 343 nm after reactions with sulfhydryl groups | | Uses | It is a water-soluble, thiol cleavable, homobifunctional and amine-reactive crosslinking agent. | | General Description | DTSSP is 3,3′-Dithiobis(sulfosuccinimidylpropionate), which contains an amine-reactive N-hydroxysulfosuccinimide (sulfo-NHS) ester at each end of an 8-carbon spacer arm. Sulfo-NHS esters react with primary amines at pH 7-9 to form stable amide bonds, along with release of the N-hydroxysulfosuccinimide leaving group. Proteins, including antibodies, generally have several primary amines in the side chain of lysine (K) residues and the N-terminus of each polypeptide that are available as targets for sulfo-NHS-ester crosslinking reagents. DSS, the non-sulfonated analog of DTSSP is also available for applications that require a membrane-permeable crosslinker. |
| 3,3'-Dithiobis(sulfosuccinimidylpropionate) Preparation Products And Raw materials |
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