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| N-(n-Nonyl)deoxynojirimycin Basic information |
| Product Name: | N-(n-Nonyl)deoxynojirimycin | | Synonyms: | (2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol;N-(n-Nonyl)-1-deoxynojirimycin min. 99%;N-Nonyldeoxynojirimycin;N-(n-Nonyl)-1-deoxynojirimycin;Nonyl-DNJ;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-nonyl-, (2R,3R,4R,5S)- | | CAS: | 81117-35-3 | | MF: | C15H31NO4 | | MW: | 289.41 | | EINECS: | | Product Categories: | All Inhibitors;Inhibitors | | Mol File: | 81117-35-3.mol |
| N-(n-Nonyl)deoxynojirimycin Chemical Properties |
| Melting point | 101-102°C | | Boiling point | 451.7±45.0 °C(Predicted) | | density | 1.112±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: >10mg/mL | | form | solid | | pka | 13.72±0.70(Predicted) |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 2933399990 |
| N-(n-Nonyl)deoxynojirimycin Usage And Synthesis |
| Chemical Properties | White Crystalline Solid | | Uses | An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. A possible therapeutic agent for Gaucher disease. | | Uses | An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. A possible therapeutic agent for Gaucher disease. | | Biological Activity | Glucosidase inhibitor (IC 50 values are 0.42 and 8.4 μ M for acid α -glucosidase and α -1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo . Also acts as a chemical chaperone; chaperones β -Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome. | | Biochem/physiol Actions | NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity. |
| N-(n-Nonyl)deoxynojirimycin Preparation Products And Raw materials |
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