Other grades of this product :
| R-(+)-DIOA Basic information |
| Product Name: | R-(+)-DIOA | | Synonyms: | R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid | | CAS: | 81166-47-4 | | MF: | C20H24Cl2O4 | | MW: | 399.31 | | EINECS: | | Product Categories: | | Mol File: | 81166-47-4.mol |
| R-(+)-DIOA Chemical Properties |
| solubility | H2O: insoluble <0.11mg/mL | | form | solid | | color | white | | optical activity | [α]27/D +18.1°, c = 0.7 in methanol(lit.) |
| R-(+)-DIOA Usage And Synthesis |
| Uses | R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system. | | Uses | R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
| | Biochem/physiol Actions | [(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system. |
| R-(+)-DIOA Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye