Other grades of this product :
| HUMAN M-CSF Basic information |
| Product Name: | HUMAN M-CSF | | Synonyms: | colony-stimulatingfactor1;csf-1;MGI-IM;Monoclonal Anti-CSF1 antibody produced in mouse;MGC31930;ANTI-M-CSF (CENTER) antibody produced in rabbit;Lanimostim;Macrophage colony-stimulating factor 1 | | CAS: | 81627-83-0 | | MF: | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| HUMAN M-CSF Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder | | color | white to off-white |
| HUMAN M-CSF Usage And Synthesis |
| Uses | Antineoplastic; anti-infective
growth factor that acts on both progenitor and mature
cells of the macrophage line. | | Uses | Macrophage Colony-Stimulating Factor from mouse has been used:- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
| | General Description | M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits. | | Biochem/physiol Actions | M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer. |
| HUMAN M-CSF Preparation Products And Raw materials |
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