4-Methyl-2-oxovaleric acid

4-Methyl-2-oxovaleric acid
  • CAS No.:816-66-0
Other grades of this product :
4-Methyl-2-oxovaleric acid Basic information
Product Name:4-Methyl-2-oxovaleric acid
Synonyms:ALPHA-KETOISOCAPROIC ACID;4-METHYL-2-OXOPENTANOIC ACID;4-METHYL-2-OXOVALERIC ACID;4-Methyl-2-oxovaleric acid >=98.0% (T);Methyl-2-oxovaleric;KETOLEUCINE;2-KETO-ISO-CAPROIC ACID;2-keto-isocaproate
CAS:816-66-0
MF:C6H10O3
MW:130.14
EINECS:212-435-5
Product Categories:
Mol File:816-66-0.mol
4-Methyl-2-oxovaleric acid Chemical Properties
Melting point 8-10 °C
Boiling point 82-83 °C11 mm Hg(lit.)
density 1.055 g/mL at 20 °C(lit.)
refractive index n20/D 1.431
FEMA 3871 | 4-METHYL-2-OXOPENTANOIC ACID
storage temp. 2-8°C
pka2.65±0.54(Predicted)
form clear liquid
color Colorless to Yellow
Water Solubility Soluble in water.
JECFA Number633
BRN 1701823
CAS DataBase Reference816-66-0(CAS DataBase Reference)
NIST Chemistry Reference4-Methyl-2-oxovaleric acid(816-66-0)
EPA Substance Registry System.alpha.-Ketoisocaproic acid (816-66-0)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR UN 3265 8/PG 3
WGK Germany 3
3-9-13
TSCA Yes
HazardClass 8
PackingGroup III
MSDS Information
ProviderLanguage
SigmaAldrich English
4-Methyl-2-oxovaleric acid Usage And Synthesis
OccurrenceReported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese.
Uses4-Methyl-2-oxovaleric acid is an intermediate in the metabolism of leucine and also used as flavoring agents.
DefinitionChEBI: A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
4-Methyl-2-oxovaleric acid Preparation Products And Raw materials
Raw materialsL-Leucine
Preparation Products4-Methyl-2-oxopentanoic acid methyl ester-->(R)-2-HYDROXY-4-METHYLPENTANOIC ACID-->L-LEUCIC ACID

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