Other grades of this product :
| (R)-(+)-SKF-38393 hydrochloride Basic information |
| (R)-(+)-SKF-38393 hydrochloride Chemical Properties |
| solubility | 0.1 M HCl: soluble1.2mg/mL | | form | solid | | color | off-white to light tan | | optical activity | [α]22/D +16.1°, c = 1.2 in methanol(lit.) |
| (R)-(+)-SKF-38393 hydrochloride Usage And Synthesis |
| Uses | (R)-(+)-SKF-38393 Hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist. | | Uses | (R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). | | Biochem/physiol Actions | (R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a?benzazepine derivative, exhibits anorectic effects. |
| (R)-(+)-SKF-38393 hydrochloride Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye