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| FTI 277 HYDROCHLORIDE Basic information |
| Product Name: | FTI 277 HYDROCHLORIDE | | Synonyms: | CS-1757;4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride;FTI 277 HYDROCHLORIDE;FTI-277 TRIFLUOROACETATE SALT;FTI 277 HCl;(S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate FTI 277 HCl;FTI 277 HCL;FTI 277;FTI 277 HYDROCHLORIDE USP/EP/BP | | CAS: | 180977-34-8 | | MF: | C22H30ClN3O3S2 | | MW: | 484.075 | | EINECS: | 604-604-1 | | Product Categories: | Inhibitors | | Mol File: | 180977-34-8.mol |
| FTI 277 HYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: soluble | | form | amorphous semi-solid |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| FTI 277 HYDROCHLORIDE Usage And Synthesis |
| Biological Activity | fti-277 is a highly potent and selective ftase inhibitor. at concentration as low as 10 nm, fti-277 inhibits h-ras processing and the processing is blocked by more than 95% at 3 μm. [1]ras proteins are plasma membrane-associated gtpases. it acts as relay switches transducing biological information from extracellular signals to the nucleus. farnesyltransferase (ftase) is an enzyme that catalyzed the ras farnesylation, a lipid posttranslational modification that is required for ras-induced malignant transformation. [1]fti-277, the methyl ester derivative of fti-276, is extremely potent (icgraphic = 100 nm) at inhibiting h-ras, but not the geranylgeranylated rap1a processing in whole cells. fti-277 is a farnesylation-specific inhibitor which inhibits the processing of both oncogenic and normal ras. [1]in mice that hydrodynamically transfected to produce hepatitis delta virus (hdv) viremia, fti-277 treatment is effective in inhibiting viremia. [2] | | references | 1. bordier bb, ohkanda j, liu p et al. in vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. j clin invest. 2003 aug;112(3):407-14.2. lerner ec, qian y, blaskovich ma et al. ras caax peptidomimetic fti-277 selectively blocksoncogenic ras signaling by inducing cytoplasmic accumulation of inactive ras-raf complexes. j biol chem. 1995 nov 10;270(45):26802-6. pubmed pmid: 7592920. |
| FTI 277 HYDROCHLORIDE Preparation Products And Raw materials |
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