Other grades of this product :
| HC TOXIN Basic information |
| Product Name: | HC TOXIN | | Synonyms: | HC TOXIN FROM HELMINTHOSPORIUM CARBONUM;Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-];Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-];HC toxin I;Toxin I;Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl);Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine);Cyclo(aoe-Pro-Ala-ala) | | CAS: | 83209-65-8 | | MF: | C21H32N4O6 | | MW: | 436.51 | | EINECS: | | Product Categories: | Cell Signaling and Neuroscience;Mold;Toxins and Venoms | | Mol File: | 83209-65-8.mol |
| HC TOXIN Chemical Properties |
| Boiling point | 819.2±65.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | lyophilized powder | | pka | 13.33±0.70(Predicted) |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| HC TOXIN Usage And Synthesis |
| Description | HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. | | Uses | HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2) | | Definition | ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues. | | Biochem/physiol Actions | Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype. |
| HC TOXIN Preparation Products And Raw materials |
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