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| KETANSERIN TARTRATE Basic information |
| Product Name: | KETANSERIN TARTRATE | | Synonyms: | R 41468;R 41468 TARTRATE SALT;3-(2-(4-(p-fluorobenzoyl)-1-piperidinyl)ethyl)-2,4(1h,3h)-quinazolinedionel;4(1h,3h)-quinazolinedione,3-(2-(4-(4-fluorobenzoyl)-1-piperidinyl)ethyl)-(;kjk-945;r-(r*,r*))-2,3-dihydroxybutanedioate(1:1);3-[2-[4-(4-fluorobenzoyl)piperidino]ethyl]quinazoline-2,4(1H,3H)-dione [R-(R*,R*)]-tartrate;KETANSERIN TARTRATE (R 41468) (SELECTIVE 5-HT2/5-HT1C SEROTONI | | CAS: | 83846-83-7 | | MF: | C26H28FN3O9 | | MW: | 545.52 | | EINECS: | 281-062-8 | | Product Categories: | Serotonin;Cardiovascular APIs;Serotonin receptor | | Mol File: | 83846-83-7.mol |
| KETANSERIN TARTRATE Chemical Properties |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 22-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | VA1411195 | | HazardClass | 6.1 | | HS Code | 29335990 | | Toxicity | LD50 oral in rat: 129mg/kg |
| KETANSERIN TARTRATE Usage And Synthesis |
| Description | Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia. | | Uses | coccidiostat | | Uses | Selective 5-HT2A serotonin receptor antagonist | | Biological Activity | Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes. | | Biochem/physiol Actions | Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction. |
| KETANSERIN TARTRATE Preparation Products And Raw materials |
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