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| Toxoflavin Basic information |
| Product Name: | Toxoflavin | | Synonyms: | Toxoflavin;1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido[5,4-e]-as-triazine;1,6-Dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione;Xanthothricin;1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido(5,4-E)-as-triazine-5,7(1H,6H)-dione;1,6-Dimethylpyrimido(5,4-E)-as-triazine-5,7(1H,6H)-dione;Brn 0021014;Nsc 67078 | | CAS: | 84-82-2 | | MF: | C7H7N5O2 | | MW: | 193.16 | | EINECS: | | Product Categories: | | Mol File: | 84-82-2.mol |
| Toxoflavin Chemical Properties |
| Melting point | 165 °C | | Boiling point | 276.7±23.0 °C(Predicted) | | density | 1.65±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: soluble10mg/mL, clear | | form | powder | | pka | -2.71±0.20(Predicted) | | color | white to light brown |
| Hazard Codes | T | | Risk Statements | 28 | | Safety Statements | 45-46 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Toxicity | LD50 in mice (mg/kg): 1.7 i.v.; 8.4 orally (Machlowitz) |
| Toxoflavin Usage And Synthesis |
| Uses | Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines. | | Uses | PKF118-310 is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling. | | Biochem/physiol Actions | PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines. |
| Toxoflavin Preparation Products And Raw materials |
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