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| Product Name: | BAPTA | | Synonyms: | BAPTA;ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID;1,2-BIS-(O-AMINOPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID;1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID;BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid;BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid;1,2-BIS(2-AMINOPHENOXY)-ETHANE-N,N,N',N'- TETRAACETIC ACID 97%;2,2',2'',2'''-[Ethylenebisoxybis(2,1-phenylenenitrilo)]tetrakisacetic acid | | CAS: | 85233-19-8 | | MF: | C22H24N2O10 | | MW: | 476.43 | | EINECS: | | Product Categories: | Aromatic;Amines;Chelating Agents & Ligands;Fluorescent Labels & Indicators;Aromatics | | Mol File: | 85233-19-8.mol |
| BAPTA Chemical Properties |
| Melting point | 177-179 °C | | Boiling point | 575.89°C (rough estimate) | | density | 1.4482 (rough estimate) | | refractive index | 1.6500 (estimate) | | RTECS | MC0423000 | | storage temp. | 2-8°C | | solubility | Soluble in dimethyl sulfoxide | | form | Powder | | pka | 1.40±0.10(Predicted) | | color | White to off-white | | Water Solubility | Soluble in water and sodium bicarbonate. | | λmax | 209 nm, 254 nm, 203 nm, 274 nm | | Merck | 14,957 | | BRN | 5192406 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | Biological Applications | Calcium indicators; zinc indicators; treating acute cell death,cerebral infarction,myocardial infarction,hepatonecrosis,kidney ischemic necrosis,necrotizing pancreatitis,amyloidosis,atherosclerosis,diseases characteriz | | InChIKey | FTEDXVNDVHYDQW-UHFFFAOYSA-N | | CAS DataBase Reference | 85233-19-8(CAS DataBase Reference) |
| BAPTA Usage And Synthesis |
| Description | BAPTA free acid (85233-19-8) is a selective extracellular Ca2+ chelator. It is a widely used calcium sponge for chelating Ca2+?outside of intact cells.1 It’s a useful tool to probe the involvement of extracellular Ca2+ in cellular signaling.2,3 Non-cell-permeable. | | Chemical Properties | White Solid | | Uses | Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels. | | Uses | BAPTA is a highly selective calcium chelating reagent. Lipophilic diesters of the chelating agent 1,2-Bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) are used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. | | Uses | As calcium chelator; 19F labelled forms for measurement of intracellular calcium. | | Definition | ChEBI: A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene. | | General Description | In nature 1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetra acetic acid (BAPTA) is a main metabolic product of BAPTA -AM (BAPTA-tetra(actoxymethyl ester), a neuro protective agent in cerebral ischemia, in rats.BAPTA is an intercellular Ca2+ chelator. | | Biological Activity | Selective calcium chelator. | | References | 1) Munoz et al. (2015), Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus; PLoS One, 10(9) e0138008
2) Wozniak et al. (2017), Extracellular Ca2+ is Required for Fertilization in the African Clawed Frog, Xenopus laevis; PLoS One, 12(1) e0170405
3) Didiasova et al. (2015), STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization; J. Biol. Chem., 290 11983 |
| BAPTA Preparation Products And Raw materials |
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