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| A-740003 Basic information |
| Product Name: | A-740003 | | Synonyms: | N-[1-[[(Cyanoamino)(5-quinolinylamino)methylene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;A-740003
N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide;N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide A-740003;N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide;A-740003, >=99%;(E)-N-(1-((Cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyp;A-740003;N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide | | CAS: | 861393-28-4 | | MF: | C26H30N6O3 | | MW: | 474.55 | | EINECS: | | Product Categories: | | Mol File: | 861393-28-4.mol |
| A-740003 Chemical Properties |
| Melting point | 128-129 °C | | density | 1.19±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear (warmed) | | pka | 14.09±0.46(Predicted) | | form | powder | | color | white to light brown |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| A-740003 Usage And Synthesis |
| Uses | A 740003 is a potent, selective and competitive P2X7 receptor antagonist. | | General Description | A-740003 is a highly affine and selective P2X7 receptor antagonist and is best for the progression of a radiotracer for imaging of neuroinflammation by positron emission tomography. | | Biological Activity | Potent, selective and competitive P2X 7 receptor antagonist (IC 50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μ M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain. | | Biochem/physiol Actions | A-740003 is a selective P2X7 purinoceptor antagonist. | | references | [1]. prisca honore, diana donnelly-roberts, marian t. namovic, et al. a-740003 [n-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective p2x7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. journal of pharmacology and experimental therapeutics, 2006, 319:1376-1385. |
| A-740003 Preparation Products And Raw materials |
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