Other grades of this product :
| SPD-304 Basic information |
| Product Name: | SPD-304 | | Synonyms: | SPD-304;CAY10500;6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;SPD-304 Exclusive;CS-2594;4H-1-Benzopyran-4-one, 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]- | | CAS: | 869998-49-2 | | MF: | C32H32F3N3O2 | | MW: | 547.61 | | EINECS: | | Product Categories: | | Mol File: | 869998-49-2.mol |
| SPD-304 Chemical Properties |
| SPD-304 Usage And Synthesis |
| Uses | SPD304 has been used in the inhibition of tumor necrosis factor receptor 1 (TNFR1) in dorsal root ganglion neurons and tumor necrosis factor alpha in colonic epithelial cell lines. | | Biochem/physiol Actions | SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM. |
| SPD-304 Preparation Products And Raw materials |
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