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| 5-(4-PHENOXYBUTOXY)PSORALEN Basic information |
| Product Name: | 5-(4-PHENOXYBUTOXY)PSORALEN | | Synonyms: | 5-(4-PHENOXYBUTOXY)PSORALEN;PAP-1;7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenoxybutoxy)-;4-(4-Phenoxybutoxy)-7H-furo[3,2-g][1]benzopyran-7-one;2-g][1]benzopyran-7-one;4-(4-phenoxybutoxy)-;7H-Furo[3;PAP-1,5-(4-Phenoxybutoxy)psoralen | | CAS: | 870653-45-5 | | MF: | C21H18O5 | | MW: | 350.36 | | EINECS: | 200-258-5 | | Product Categories: | API intermediates | | Mol File: | 870653-45-5.mol |
| 5-(4-PHENOXYBUTOXY)PSORALEN Chemical Properties |
| density | 1.269 | | storage temp. | 2-8°C | | solubility | DMSO: 9 mg/mL | | form | solid | | color | white |
| 5-(4-PHENOXYBUTOXY)PSORALEN Usage And Synthesis |
| Uses | 5-(4-Phenoxybutoxy)psoralen (CAS# 870653-45-5) is a selective small molecule blocker of the lymphocyte K+ channel Kv1.3 and is used for the suppression of effector memory T cells in autoimmune diseases. | | Biochem/physiol Actions | Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels. |
| 5-(4-PHENOXYBUTOXY)PSORALEN Preparation Products And Raw materials |
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