Other grades of this product :
| 15D-PGJ2 Basic information |
| Product Name: | 15D-PGJ2 | | Synonyms: | 15-deoxy-Δ12,14-Prostaglandin J2 Lipid Maps MS Standard;11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid;15-Deoxy-Δ12,14-PGJ2;15-deoxy-Δ12,14-Prostaglandin J2 solution;15d-PGJ?;15D-PGJ2;15-DEOXY-DELTA12,14-PROSTAGLANGIN J2;15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2 | | CAS: | 87893-55-8 | | MF: | C20H28O3 | | MW: | 316.43 | | EINECS: | 201-185-2 | | Product Categories: | | Mol File: | 87893-55-8.mol |
| 15D-PGJ2 Chemical Properties |
| Fp | -9℃ | | storage temp. | -20°C | | form | methyl acetate solution |
| 15D-PGJ2 Usage And Synthesis |
| Uses | 15-Deoxy-Δ12,14-prostaglandin J2 has been used: - to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
| | General Description | A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding. | | Biological Activity | Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M). | | Biochem/physiol Actions | 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis. |
| 15D-PGJ2 Preparation Products And Raw materials |
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