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| DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE Basic information |
| DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE Chemical Properties |
| Melting point | 180-182?C | | density | 1.320 g/cm3 | | storage temp. | 2-8°C | | solubility | H2O: soluble | | form | powder | | color | white to off-white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | DA4798000 |
| DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | Off-White to Pale Yellow Solid | | Uses | A metabolite of Epinephrine (E588585). A naturraly occurring derivative of Epinephrine, found in urine and in certain tissues. | | Biochem/physiol Actions | Metanephrine is an endogenous metabolite of ephinephrine, formed by catechol-O-methyl transferase activity. It is best known as a biomarker for cancers, as levels of free metanephrine are used to diagnose pheochromocytoma. Metanephrine was previously thought to be biologically inactive, but it is a more potent agonist at Trace amine associated receptor TAAR1 than either epinephrine or norepinephrine. Trace amine associated receptors (TAARs) are recently discovered GPCRs that are activated by endogenous trace amines (tyramine, tryptamine, synephrine, octopamine, β-phenylethylamine), which are chemically similar to monoaminergic neurotransmitters (epinephrine, norepinephrine, dopamine). Trace amines and TAARs are expressed in brain and are implicated in modulation of monoaminergic neurotransmission. |
| DL-M-O-METHYLEPINEPHRINE HYDROCHLORIDE Preparation Products And Raw materials |
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