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| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Basic information |
| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Chemical Properties |
| Melting point | 241-243°C | | storage temp. | room temp | | solubility | H2O: Stock solutions of 5 mM are recommended. These stocks should be stable for up to 6 months when stored at 4°C.soluble | | form | powder | | color | white | | CAS DataBase Reference | 88519-57-7(CAS DataBase Reference) |
| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Usage And Synthesis |
| Description | W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities. | | Chemical Properties | Beige Solid | | Uses | W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities. | | Uses | Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127, it is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
| | Biological Activity | Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells. | | Biochem/physiol Actions | W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells. |
| N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials |
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