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| CHEMBRDG-BB 5280909 Basic information |
| Product Name: | CHEMBRDG-BB 5280909 | | Synonyms: | CHEMBRDG-BB 5280909;(1-METHYL-5-NITRO-3-PHENYL-1H-INDOL-2-YL)METHANOL;(1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol(SALTDATA: FREE);ML-354;1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol | | CAS: | 89159-60-4 | | MF: | C16H14N2O3 | | MW: | 282.29 | | EINECS: | | Product Categories: | | Mol File: | 89159-60-4.mol |
| CHEMBRDG-BB 5280909 Chemical Properties |
| storage temp. | -20°C | | solubility | ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | powder | | color | white to beige |
| RIDADR | UN 2811 6.1 / PGIII |
| CHEMBRDG-BB 5280909 Usage And Synthesis |
| Description | ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC50 = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC50 = 10 μM) in isolated human platelets. | | Uses | ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects. | | Biochem/physiol Actions | ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist. | | IC 50 | 140 nm | | references | [1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713. |
| CHEMBRDG-BB 5280909 Preparation Products And Raw materials |
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