Other grades of this product :
| CATHEPSIN D Basic information |
| Product Name: | CATHEPSIN D | | Synonyms: | CATHEPSIN D;CATHEPSIN D, BOVINE;CATHEPSIN D, BOVINE KIDNEY;CATHEPSIN D, BOVINE SPLEEN;CATHEPSIN D, HUMAN;CATHEPSIN D, HUMAN LIVER;CATHEPSIN D, HUMAN SPLEEN;EC 3.4.22.5 | | CAS: | 9025-26-7 | | MF: | NULL | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| CATHEPSIN D Chemical Properties |
| storage temp. | -20°C | | form | lyophilized powder | | color | white | | Water Solubility | Reconstitute in water at 1µg/µl |
| CATHEPSIN D Usage And Synthesis |
| Uses | Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer. | | Uses | Cathepsin D from human liver has been used:- in β-secretase activity assay
- for enzymatic degradation of amyloid β 1-42
- in microinjection of human foreskin fibroblasts
| | General Description | Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis. | | Biochem/physiol Actions | Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced. | | Purification Methods | Cathepsin D is purified on a CM column after (NH4)2SO4 fractionation and dialysis, then starch-gel electrophoresis and by ultracentrifugal analysis. Finally chromatograph on a DEAE column [Press et al. Biochem J 74 501 1960]. |
| CATHEPSIN D Preparation Products And Raw materials |
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