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| 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Basic information |
| 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Chemical Properties |
| Melting point | 224-225 °C(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: 0.1 g/mL, clear | | form | Solid | | color | Colorless crystals | | Water Solubility | Soluble in water. | | BRN | 4007967 | | Stability: | Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Hazard Codes | T,N | | Risk Statements | 25-50/53 | | Safety Statements | 45-60-61 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | F | 8 | | TSCA | Yes | | HS Code | 2933 99 80 | | HazardClass | 6.1 | | PackingGroup | III | | Toxicity | LD50 orally in Rabbit: 132 mg/kg |
| 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Usage And Synthesis |
| Description | 1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1? It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+.? It may be used when preparing cell lysates for enrichment of ubiquitinated proteins? which are especially sensitive to DUBs in the JAMM family.2,3 | | Chemical Properties | White fine crystalline powder | | Uses | 1,10-Phenanthroline monohydrochloride monohydrate is used as an analytical reagent for colorimetric determination of iron. | | References | 1) Swann?et al?(1981)?Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J.,?195?41
2) Cooper?et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J.,?28?621
3) Lu?et al. (2015)?Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science,?348?200 |
| 1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Preparation Products And Raw materials |
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