1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE

CAS No.：18851-33-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Basic information

Product Name:	1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE
Synonyms:	1,10-PHENANTHROLINE HYDROCHLORIDE;1,10-PHENANTHROLINE CHLORIDE MONOHYDRATE;1,10-PHENANTHROLINE HYDROCHLORIDE MONOHYDRATE;1,10-PHENANTHROLINE HYDROCHLORIDE MONOHYDRATE (O-);1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE;1,10-Phenanthroline monohydrochloride monohydrate 97%;1,10-Phenanthroline hydrochloride hydrate (1:1:1);O-PHENANTHROLINE HYDROCHLORIDE MONOHYDRATE
CAS:	18851-33-7
MF:	C12H11ClN2O
MW:	234.68
EINECS:	627-064-8
Product Categories:	Amine Salts;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Antibiotics;Antibiotics A to Z;Antibiotics N-S;Heterocyclic Building Blocks;N-Containing;Others
Mol File:	18851-33-7.mol

1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Chemical Properties

Melting point	224-225 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 0.1 g/mL, clear
form	Solid
color	Colorless crystals
Water Solubility	Soluble in water.
BRN	4007967
Stability:	Stable for 2 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Safety Information

Hazard Codes	T,N
Risk Statements	25-50/53
Safety Statements	45-60-61
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
F	8
TSCA	Yes
HS Code	2933 99 80
HazardClass	6.1
PackingGroup	III
Toxicity	LD50 orally in Rabbit: 132 mg/kg

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Usage And Synthesis

Description	1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1? It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+.? It may be used when preparing cell lysates for enrichment of ubiquitinated proteins? which are especially sensitive to DUBs in the JAMM family.2,3
Chemical Properties	White fine crystalline powder
Uses	1,10-Phenanthroline monohydrochloride monohydrate is used as an analytical reagent for colorimetric determination of iron.
References	1) Swann?et al?(1981)?Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J.,?195?41 2) Cooper?et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J.,?28?621 3) Lu?et al. (2015)?Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science,?348?200

1,10-PHENANTHROLINIUM CHLORIDE MONOHYDRATE Preparation Products And Raw materials

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