Other grades of this product :
| EC 2.4.2.4 Basic information |
| Product Name: | EC 2.4.2.4 | | Synonyms: | EC 2.4.2.4;THYMIDINE PHOSPHORYLASE FROM*ESCHERICHIA COLI;THYMIDINE PHOSPHORYLASE, RECOMBINANT*FRO M E. COLI;THYMIDINE PHOSPHORYLASE, ASEPTICALLY*FIL LED, FROM E;thymidine:orthophosphate deoxy-d-ribosyltransferase;Thymidine Phosphorylase, recombinant from Escherichia coli;MNGIE;ANTI-ECGF1 (CENTER) antibody produced in rabbit | | CAS: | 9030-23-3 | | MF: | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| EC 2.4.2.4 Chemical Properties |
| storage temp. | 2-8°C | | form | buffered aqueous solution |
| EC 2.4.2.4 Usage And Synthesis |
| Uses | Thymidine phosphorylase has been used in a study to evaluate biomarkers for advanced breast cancer patients treated with capecitabine-based first-line chemotherapy. Thymidine phosphorylase has also been used in a study to investigate implications for the clinical efficacy of nucleoside analogues. | | Uses | Thymidine phosphorylase has been used in a study to assess TAS-102 treatment in patients with advanced solid tumors. Thymidine phosphorylase has also been used in a study to investigate antitumor effects of the FP3 protein on patient-derived tumor tissue xenograft models of primary colon carcinoma. | | General Description | Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation. | | Biochem/physiol Actions | An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays. |
| EC 2.4.2.4 Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye