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| CALCINEURIN Basic information |
| Product Name: | CALCINEURIN | | Synonyms: | Calcineurin bovine brain;CALCINEURIN FROM BOVINE BRAIN, >10 U/MG;calcium/calmodulin-activated protein phosphatase;MODULATOR BINDING PROTEIN;PP2B;PPASE-2B;PROTEIN PHOSPHATASE 2B, HUMAN, RECOMBINANT, E COLI;PROTEIN PHOSPHATASE 2B | | CAS: | 90371-51-0 | | MF: | | MW: | 0 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| CALCINEURIN Chemical Properties |
| storage temp. | −20°C | | solubility | H2O: soluble | | form | lyophilized powder |
| CALCINEURIN Usage And Synthesis |
| Uses | Calcineurin from bovine brain has been used: - as a positive control in western blot analysis of oocytes and cumulus cells proteome
- as a positive control in calmodulin (CaM)-agarose binding assay
- to test its phosphatase activity in the presence of okadaic acid
| | General Description | Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain. | | Biochem/physiol Actions | Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells. |
| CALCINEURIN Preparation Products And Raw materials |
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