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| RO 15-4513 Basic information |
| Product Name: | RO 15-4513 | | Synonyms: | RO 15-4513;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;Azidomazenil;Ethyl 8-azido-6-dihyro-5-methyl-6-oxo-4H-imidazo[1,5-A][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester | | CAS: | 91917-65-6 | | MF: | C15H14N6O3 | | MW: | 326.31 | | EINECS: | | Product Categories: | GABA/Glycine receptor | | Mol File: | 91917-65-6.mol |
| RO 15-4513 Chemical Properties |
| storage temp. | Desiccate at +4°C | | solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL | | form | solid | | color | tan | | CAS DataBase Reference | 91917-65-6 |
| RO 15-4513 Usage And Synthesis |
| Description | Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors. | | Chemical Properties | Off-white solid | | Uses | Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies. | | Uses | Ro 15-4513 is an alcohol antagonist. | | Application | Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine. | | Biological Activity | High affinity benzodiazepine ligand. K i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α 1-, α 2-, α 3- and α 5-GABA A receptors. Displays partial agonism at DI α 4- and α 6-GABA A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic. | | Biochem/physiol Actions | Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine. |
| RO 15-4513 Preparation Products And Raw materials |
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