Other grades of this product :
| RO 25-6981 HYDROCHLORIDE Basic information |
| Product Name: | RO 25-6981 HYDROCHLORIDE | | Synonyms: | [R-(R*,S*)]-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL HYDROCHLORIDE;4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride;[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride hydrate;Ro 25-6981 hydrochloride hydrate;Ro 25 6981 HCl;Ro 256981 HCl;Ro 25-6981 HCl | | CAS: | 919289-58-0 | | MF: | C22H30ClNO2 | | MW: | 375.93 | | EINECS: | | Product Categories: | Glutamate receptor | | Mol File: | 919289-58-0.mol |
| RO 25-6981 HYDROCHLORIDE Chemical Properties |
| solubility | H2O: 2 mg/mL | | form | powder | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| RO 25-6981 HYDROCHLORIDE Usage And Synthesis |
| Uses | Ro 25-6981 hydrochloride hydrate has been used:- as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
- as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
- to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus
| | Biochem/physiol Actions | Potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit. |
| RO 25-6981 HYDROCHLORIDE Preparation Products And Raw materials |
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