Other grades of this product :
| Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Basic information |
| Product Name: | Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate | | Synonyms: | Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate;PDI inhibitor 16F16;2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester;1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester;PDI inhibitor 16F16 >=98% (HPLC) | | CAS: | 922507-80-0 | | MF: | C16H17ClN2O3 | | MW: | 320.77 | | EINECS: | | Product Categories: | | Mol File: | 922507-80-0.mol |
| Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble12mg/mL, clear | | form | powder | | color | white to tan |
| Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Usage And Synthesis |
| Uses | PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies. | | Biochem/physiol Actions | 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation. |
| Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Preparation Products And Raw materials |
|
![Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate](/img/922507-80-0.jpg "Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate")
日本语
한국어
Français
Deutsch
España
Türkiye