2-(4-Isopropylpheny)-4H-chroMen-4-one

CAS No.：92831-11-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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2-(4-Isopropylpheny)-4H-chroMen-4-one Basic information

Product Name:	2-(4-Isopropylpheny)-4H-chroMen-4-one
Synonyms:	MN-64;2-(4-Propan-2-ylphenyl)chromen-4-one;2-(4-Isopropylpheny)-4H-chroMen-4-one;2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one;MN64; MN 64;2-(4-Isopropyl-phenyl)-chromen-4-one;MN64, >98%;4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]-
CAS:	92831-11-3
MF:	C18H16O2
MW:	264.32
EINECS:
Product Categories:
Mol File:	92831-11-3.mol

2-(4-Isopropylpheny)-4H-chroMen-4-one Chemical Properties

Melting point	63-64 °C(Solv: ethanol (64-17-5))
Boiling point	389.8±42.0 °C(Predicted)
density	1.152±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
color	white to beige

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3

MSDS Information

2-(4-Isopropylpheny)-4H-chroMen-4-one Usage And Synthesis

Uses	2-[4-(1-Methylethyl)phenyl4H-1-benzopyran-4-one is a potent and selective tankyrase (TNKS) inhibitor affecting cell proliferation with potential treatment for cancers. Flavonoid compound with anti-cancer/ anti-bacterial properties.
Biological Activity	mn-64 is a type of flavone that act as a potent and selective tankyrase inhibitor (ic50 = 6 and 72 nm for tnks1 and tnks2, respectively). [1]tankytase (tnks) is a member of poly adp ribose polymerases (parps). there are two related homologue, tnks1 and tnks2 that are mostly located in the nuclear pore, cytoplasm, mitotic centrosomes and the golgi apparatus. they involve in cellular functions such as regulation of cell proliferation and promoting telomere elongation in human cells. [1]during an assay for screening flavone tnks inhibitors, mn-64 is discovered for abrogating stf luciferase activity at 200nm and potently inhibiting tnks1 with ic50 of 6nm. it also selectively inhibits tnks1 and tnks2 without affecting any other parps. moreover, mn-64 is prominently more selective than other tnks inhibitors such as xav939. [1]
Biochem/physiol Actions	MN-64 is a very potent inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). The compound MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system.
references	1. narwal m, koivunen j, haikarainen t et al. discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. j med chem. 2013 oct 24;56(20):7880-9.

2-(4-Isopropylpheny)-4H-chroMen-4-one Preparation Products And Raw materials

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