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| PPQ-102 Basic information |
| Product Name: | PPQ-102 | | Synonyms: | CS-1365;CFTR Inhibitor;CFTR INHIBITOR; PPQ102; PPQ 102;CFTR Inhibitor IV, PPQ-102 - CAS 931706-15-9 - Calbiochem;PPQ-102;7,9-DIMETHYL-6-(5-METHYL-2-FURYL)-11-PHENYL-6,7-DIHYDROPYRIMIDO[4 ',5':3,4]PYRROLO[1,2-A]QUINOXALINE-8,10(5H,9H)-DIONE;PPQ-102, CFTR Inhibitor;6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione | | CAS: | 931706-15-9 | | MF: | C26H22N4O3 | | MW: | 438.48 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 931706-15-9.mol |
| PPQ-102 Chemical Properties |
| Melting point | >300℃ (ethanol ) | | Boiling point | 648.7±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | -20C | | form | White crystalline solid | | pka | 1.00±0.40(Predicted) |
| PPQ-102 Usage And Synthesis |
| General Description | A cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) compound that targets the intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR-mediated chloride current in a reversible and voltage-independent manner. Single channel recordings of CFTR-expressing FRT cells upon forskolin (Cat. No. 344270) and IBMX (Cat. No. 410957) stimulation indicate that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state (7.8- vs. 0.4-fold increase of mean channel close vs. open time, respectively, with 1 μM PPQ-102). PPQ-102 at 5 μM is shown to completely prevent Sp-8-Br-cAMP- (Cat. No. 116818) induced cysts formation and reduce the size of preformed cysts in an ex vivo murine neonatal kidney organ culture. |
| PPQ-102 Preparation Products And Raw materials |
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