1-HYDROXY-1-CYCLOHEXANECARBONITRILE

CAS No.：931-97-5

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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1-HYDROXY-1-CYCLOHEXANECARBONITRILE Basic information

Product Name:	1-HYDROXY-1-CYCLOHEXANECARBONITRILE
Synonyms:	CYCLOHEXANONE CYANOHYDRIN;1-HYDROXY-1-CYCLOHEXANECARBONITRILE;1-HYDROXY-CYCLOHEXANECARBONITRILE;1-Hydroxy-cyclohexancarbonitril;1-hydroxy-cyclohexanecarbonitril;CYCLOHEXANECARBONITRILE,1-HYDROXY-;1-Cyano-1-hydroxycyclohexane;1-Hydroxy-1-cyanocyclohexane
CAS:	931-97-5
MF:	C7H11NO
MW:	125.17
EINECS:	213-246-0
Product Categories:	Miscellaneous;Cycloalkanes
Mol File:	931-97-5.mol

1-HYDROXY-1-CYCLOHEXANECARBONITRILE Chemical Properties

Melting point	32-35 °C (lit.)
Boiling point	132 °C/19 mmHg (lit.)
density	1.031
refractive index	1.4693
Fp	>230 °F
storage temp.	2-8°C
pka	11.45±0.20(Predicted)
CAS DataBase Reference	931-97-5(CAS DataBase Reference)
EPA Substance Registry System	Cyclohexanone cyanohydrin (931-97-5)

Safety Information

Hazard Codes	T+
Risk Statements	28
Safety Statements	45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	GU7710000
TSCA	Yes
HazardClass	6.1
PackingGroup	II

MSDS Information

Provider	Language
SigmaAldrich	English

1-HYDROXY-1-CYCLOHEXANECARBONITRILE Usage And Synthesis

Uses	Cyclohexanone cyanohydrin was employed as substrate during high-throughput screening assay for hydroxynitrile lyase activity. It was used in preparation of 1-aminomethyl cyclohexanol via catalytic hydrogenation reaction.
Synthesis Reference(s)	Tetrahedron Letters, 19, p. 3773, 1978 DOI: 10.1016/S0040-4039(01)95055-5
General Description	Brown solid.
Air & Water Reactions	Water soluble. Reacts slowly with water .
Reactivity Profile	1-HYDROXY-1-CYCLOHEXANECARBONITRILE is an a-hydroxonitrile. Incompatible with acids; mixing nitriles with strong oxidizing acids can lead to violent reactions. Incompatible with oxidizing agents such as peroxides and epoxides. Mixing with bases can produce poisonous and flammable hydrogen cyanide. May be hydrolyzed exothermically in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). May react vigorously with reducing agents.
Fire Hazard	Flash point data regarding 1-HYDROXY-1-CYCLOHEXANECARBONITRILE are not available, however, 1-HYDROXY-1-CYCLOHEXANECARBONITRILE is probably combustible.

1-HYDROXY-1-CYCLOHEXANECARBONITRILE Preparation Products And Raw materials

Preparation Products

1-hydroxycyclohexane-1-carboxamide-->ETHYL 1-HYDROXYCYCLOHEXANE-CARBOXYLATE-->1-(aminomethyl)cyclohexan-1-ol

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