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| N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Basic information |
| Product Name: | N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide | | Synonyms: | CYM5541;CYM-5541;ML249;N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide;N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide;CYM 5541(ML-249);CYM-5541;CYM 5541;ML-249;ML 249;ML249;N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide | | CAS: | 945128-26-7 | | MF: | C19H28N2O2 | | MW: | 316.44 | | EINECS: | | Product Categories: | | Mol File: | 945128-26-7.mol |
| N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Chemical Properties |
| Boiling point | 503.1±38.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | pka | -2.57±0.20(Predicted) | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Usage And Synthesis |
| Description | The sphingosine 1-phosphate (S1P) receptor S1P3 has roles in vasodilation, epithelial barrier function, cardioprotection, fibrosis, immunity, and inflammation. CYM 5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM). It less effectively activates S1P1 (EC50 = 28-38 μM) and is ineffective at S1P2, S1P4, and S1P5 as well as a panel of other receptors, ion channels and transporters. | | Uses | CYM 5541, is a selective allosteric agonist of SAR and S1P3 receptors. | | Biochem/physiol Actions | CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC50 of between 72 and 132 nM compared to S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters. | | References | 1) Guerrero?et al.?(2011),?Probe Development Efforts for an Allosteric Agonist of Sphingosine 1-phosphate Receptor 3 (S1P3); Probe Reports from the NIH Molecular Libraries Program
2) Jo?et al.?(2012),?Novel Selective Allosteric and Bitopic Ligands for the S1P3 Receptor; ACS Chem. Biol.?7?1975 |
| N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide Preparation Products And Raw materials |
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