(R)-N-Fmoc-2-(7'-octenyl) alanine

(R)-N-Fmoc-2-(7'-octenyl) alanine
  • CAS No.:945212-26-0
Other grades of this product :
(R)-N-Fmoc-2-(7'-octenyl) alanine Basic information
Product Name:(R)-N-Fmoc-2-(7'-octenyl) alanine
Synonyms:(R)-N-Fmoc-2-(7'-octenyl) alanine;(2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-9-decenoic acid;(R)-N-(9-Fluorenylmethylcarbamate)-2-(2'-octenyl)alanine;(R)-N-FMoc-2-(7'-octenyl) alanine, 97%Min;(R)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-2-Methyldec-9-enoic acid;(R)-N-FMOC-Α-(7-OCTENYL)ALANINE;FMoc-α-Me-D-Gly(Octenyl)-OH;(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methyldec-9-enoic acid
CAS:945212-26-0
MF:C26H31NO4
MW:421.53
EINECS:
Product Categories:α-Methyl Amino Acids
Mol File:945212-26-0.mol
(R)-N-Fmoc-2-(7'-octenyl) alanine Chemical Properties
Boiling point 588.3±45.0 °C(Predicted)
density 1.140
storage temp. -20°C
pka3.94±0.41(Predicted)
form liquid
color pale yellow viscous
Safety Information
Hazard Codes N
Risk Statements 50
Safety Statements 61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
TSCA No
HS Code 2922498590
MSDS Information
(R)-N-Fmoc-2-(7'-octenyl) alanine Usage And Synthesis
Uses(2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-9-decenoic Acid, is a stable antimicrobial peptide, that can be isolated from the venom of wild bee Lasioglossum laticeps.
UsesOlefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.
(R)-N-Fmoc-2-(7'-octenyl) alanine Preparation Products And Raw materials
Raw materials(R)-2-amino-2-methyldec-9-enoic acid HCl-->N-(9-Fluorenylmethoxycarbonyloxy)succinimide

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