5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE

CAS No.：947-95-5

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5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Basic information

Product Name:	5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
Synonyms:	5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE;5-CHLORO-3-METHYL-1-PHENYL-4-PYRAZOLECARBOXALDEHYDE;5-CHLORO-3-METHYL-1-PHENYL PYRAZOLE-4-ALDEHYDE;5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE-4-CARBALDEHYDE;5-CHLORO-3-METHYL-1-PHENYLPYRAZOLE-4-CARBOXALDEHYDE;5-CHLORO-4-FORMYL-3-METHYL-1-PHENYLPYRAZOLE;OTAVA-BB BB0111070359;AKOS BBS-00001388
CAS:	947-95-5
MF:	C11H9ClN2O
MW:	220.65
EINECS:
Product Categories:	Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrazoles;PyrazolesHeterocyclic Building Blocks
Mol File:	947-95-5.mol

5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties

Melting point	145-148 °C (lit.)
Boiling point	356.1±37.0 °C(Predicted)
density	1.26
refractive index	1.6000 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-3.81±0.10(Predicted)
form	powder to crystal
color	White to Light yellow
CAS DataBase Reference	947-95-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29331990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Usage And Synthesis

Chemical Properties	light yellow to yellow flakes or needles
Uses	5-Chloro-3-methyl-1-phenyl-4-pyrazolecarboxaldehyde (5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde) may be employed as starting material for the following syntheses: 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde hydrazone N¹-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene)thiosemicarbazone pyrazole derivatives, which were pharmacologically evaluated for analgesic (tail flick) and anti-inflammatory (based on carrageenan-induced paw edema) activities N′-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4- yl)methylene] 2/4-substituted hydrazides
General Description	5-Chloro-3-methyl-1-phenyl-4-pyrazolecarboxaldehyde (5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde) can be synthesized from 3-methyl-1-phenyl-1Hpyrazol-5(4H)-one under Vilsmeier-Haack reaction conditions. Knoevenagel condensation of 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde with ethylcyanoacetate at 0°C has been reported to afford ethyl-2-cyano-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-yl)propionate. It participates in the synthesis of 2-((5-phenoxy-3-methyl-1-phenyl-1H-pyrazol- 4-yl)methylene)hydrazinecarbothiomide derivatives with a potential anticonvulsant property.

5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE Preparation Products And Raw materials

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