Other grades of this product :
| SID 24769845 Basic information |
| Product Name: | SID 24769845 | | Synonyms: | 1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide;AS-136A;CID 16122506;SID 24769845;2-methyl-N-(4-piperidin-1-ylsulfonylphenyl)-5-(trifluoromethyl)pyrazole-3-carboxamide | | CAS: | 949898-66-2 | | MF: | C17H19F3N4O3S | | MW: | 416.42 | | EINECS: | | Product Categories: | | Mol File: | 949898-66-2.mol |
| SID 24769845 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | powder | | color | white to off-white |
| Hazard Codes | Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 |
| SID 24769845 Usage And Synthesis |
| Uses | AS-136A is a small molecule developed as part of the NIH Probes effort. AS-136A is a potent measles virus (MeV) RNA-dependent RNA polymerase (RdRp) inhibitor. AS-136A is very stable, decreases virus titer after 24 hours in physiological conditions, and serves as a positive control in MeV inhibitory assays. | | Biochem/physiol Actions | AS-136A is a potent measles virus RdRp inhibitor. Measles virus (MV) is a member of the paramyxovirus family. Ribavirin (R9644) is the only drug available for treatment of paramyxoviruses, and it has limited efficacy against MV. A series of small molecules has been developed to inhibit viral RNA-dependent RNA polymerase (RdRp), a protein vital to infection leading to the development of AS-136A, a very potent RdRp inhibitor. AS-136A has high stability and continues to decrease virus titer after 24 hours in physiologic conditions. AS-136A is now used as a positive control in experiments assaying MV inhibition. This compound is a product of the NIH Probes effort, also known as SID 24769845. |
| SID 24769845 Preparation Products And Raw materials |
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