Other grades of this product :
| NSC 150117 hydrochloride Basic information |
| Product Name: | NSC 150117 hydrochloride | | Synonyms: | (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one;(E/Z)-BCI hydrochloride;2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride;3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one;NSC 150117 hydrochloride;BCI (hydrochloride);(E/Z)-BCI;BCI hydrochloride - NSC 150117 hydrochloride | | CAS: | 95130-23-7 | | MF: | C22H24ClNO | | MW: | 353.885 | | EINECS: | | Product Categories: | | Mol File: | 95130-23-7.mol |
| NSC 150117 hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | color | white to beige |
| NSC 150117 hydrochloride Usage And Synthesis |
| Uses | (E/Z)-BCI hydrochloride has been used:- to evaluate the role of the Duox-H2O2-Dusp6 derepression signaling pathway in heart regeneration
- as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects
- as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells
| | Biochem/physiol Actions | BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling. |
| NSC 150117 hydrochloride Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye