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| 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Basic information |
| 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Chemical Properties |
| 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Usage And Synthesis |
| Uses | 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S?M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine. |
| 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Preparation Products And Raw materials |
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