3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine

CAS No.：952143-02-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Basic information

Product Name:	3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
Synonyms:	3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine;3H-Diazirine, 3-(4-bromophenyl)-3-(trifluoromethyl)-
CAS:	952143-02-1
MF:	C8H4BrF3N2
MW:	265.03
EINECS:
Product Categories:
Mol File:	952143-02-1.mol

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Chemical Properties

storage temp.

2-8°C

Safety Information

MSDS Information

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Usage And Synthesis

Uses

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S?M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine Preparation Products And Raw materials

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