Other grades of this product :
| CRT-0066101 Basic information |
| Product Name: | CRT-0066101 | | Synonyms: | CRT 0066101;CRT0066101;CRT-0066101;SCJXQZZYGYLKJG-CQSZACIVSA-N;6-6-(2R)-2-Aminobutylamino-1H-pyrimidin-2-ylidene-4-(1-methylpyrazol-4-yl)cyclohexa-2,4-dien-1-one,hydrochloride | | CAS: | 956123-34-5 | | MF: | C18H22N6O | | MW: | 338.41 | | EINECS: | | Product Categories: | | Mol File: | 956123-34-5.mol |
| CRT-0066101 Chemical Properties |
| storage temp. | -20°C | | form | powder | | color | white to beige |
| CRT-0066101 Usage And Synthesis |
| Biochem/physiol Actions | CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms with IC50 values for PKD-1, -2 and -3 = 1, 2.5 and 2 nM, respecitively. CRT0066101 has been shown to have anticancer activity. CRT0066101 potently inhibits proliferation of PANC-1 pancreatic cells, and blocks migration and invasion of U87MG glioblastoma cells. CRT0066101 has also been shown to decrease growth of primary tumors and metastasis of ER(-) breast cancers. |
| CRT-0066101 Preparation Products And Raw materials |
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