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| H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE Basic information |
| Product Name: | H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE | | Synonyms: | EDF;EXTRACELLULAR DEATH FACTOR;H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE;IL-5 from mouse;BCDFII;Extracellular Death Factor, EDF;Extracellular death factor (synthetic Escherichia coli);L-Asparaginyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-asparagine | | CAS: | 960129-66-2 | | MF: | C27H36N10O10 | | MW: | 660.64 | | EINECS: | | Product Categories: | | Mol File: | 960129-66-2.mol |
| H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | colorless |
| H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE Usage And Synthesis |
| Uses | Extracellular Death Factor (ECF) is the dramatic name given to an interesting linear pentapeptide produced by E. coli, first identified by Engelberg-Kulka and colleagues in 2007 and published in Science. ECF acts as a quorum sensing agent, regulating bacterial cell density by balancing the levels of toxin and antitoxin via mazEF-mediated cell death genes. | | General Description | IL-5 (interleukin 5) is a Th2 (T helper 2) cytokine that is predominantly produced by T lymphocytes, and to a lower extent by mast cells, type 2 innate lymphoid (ILC2) cells, and eosinophils.Recombinant murine IL-5 is a 26.2kDa disulfide-linked homodimeric protein containing two 113 amino acid chains. | | Biochem/physiol Actions | IL-5 (interleukin 5) was initially identified as a stimulant of antibody production by activated B cells. It has recently been shown to be a key factor in eosinophil differentiation and proliferation. It is also implicated in the pathogenesis of asthma, atopy, hypereosinophilic syndromes, and parasitic infections. In distal lung, IL-5 recruits eosinophils and modulates inflammatory or immune cells in the microenvironment, thus, promoting lung metastasis in cancer. |
| H-ASN-ASN-TRP-ASN-ASN-OH TRIFLUOROACETATE Preparation Products And Raw materials |
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