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| INDATRALINE HYDROCHLORIDE Basic information |
| Product Name: | INDATRALINE HYDROCHLORIDE | | Synonyms: | INDATRALINE HYDROCHLORIDE;LU 19-005;(+/-)-TRANS-3-(3,4-DICHLOROPHENYL)-N-METHYL-1-INDANAMINE HYDROCHLORIDE;INDATRALINE HCL (POTENT INHIBITOR OF DOP AMINENOREPINEPHRINE AND SE;Lu 19-005, (±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride;EOS 60004;(1R,3S)-REL-3-(3,4-DICHLOROPHENYL)-2,3-DIHYDRO-N-METHYL-1H-INDEN-1-AMINE HYDROCHLORIDE;3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine | | CAS: | 96850-13-4 | | MF: | C16H16Cl3N | | MW: | 328.66 | | EINECS: | | Product Categories: | Serotonin receptor | | Mol File: | 96850-13-4.mol |
| INDATRALINE HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | 0.1 M HCl: 1 mg/mL | | form | solid | | color | white |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | 3 |
| INDATRALINE HYDROCHLORIDE Usage And Synthesis |
| Uses | Indatraline Hydrochloride?inhibits the synaptosomal uptake of 3,4-dihydroxyphenylethylamine (dopamine, DA), noradrenaline (NA), and 5-hydroxytryptamine (5-HT, serotonin). | | Uses | Indatraline hydrochloride has been used:- as a competitive inhibitor of 3H-dopamine ([3H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
- as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
- as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)
| | Biochem/physiol Actions | Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy. |
| INDATRALINE HYDROCHLORIDE Preparation Products And Raw materials |
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