S(-)-BAY K 8644

CAS No.：98625-26-4

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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S(-)-BAY K 8644 Basic information

Product Name:	S(-)-BAY K 8644
Synonyms:	S(-)-BAY K 8644;(4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO;(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester;s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester;[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester;BAY-r-5417;R-5417
CAS:	98625-26-4
MF:	C16H15F3N2O4
MW:	356.3
EINECS:
Product Categories:	Calcium channel
Mol File:	98625-26-4.mol

S(-)-BAY K 8644 Chemical Properties

storage temp.	2-8°C
solubility	H₂O: slightly soluble
form	solid
color	yellow

Safety Information

Hazard Codes	Xi
Risk Statements	36/38
Safety Statements	26-36
WGK Germany	3
HS Code	2933399990

MSDS Information

Provider	Language
SigmaAldrich	English

S(-)-BAY K 8644 Usage And Synthesis

Uses	(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia?in rats.
General Description	(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺?channel activator. It is an enantiomer of Bay K 8644.
Biological Activity	L-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ).
Biochem/physiol Actions	(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

S(-)-BAY K 8644 Preparation Products And Raw materials

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