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| S(-)-BAY K 8644 Basic information |
| Product Name: | S(-)-BAY K 8644 | | Synonyms: | S(-)-BAY K 8644;(4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO;(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester;s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester;[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester;BAY-r-5417;R-5417 | | CAS: | 98625-26-4 | | MF: | C16H15F3N2O4 | | MW: | 356.3 | | EINECS: | | Product Categories: | Calcium channel | | Mol File: | 98625-26-4.mol |
| S(-)-BAY K 8644 Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: slightly soluble | | form | solid | | color | yellow |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2933399990 |
| S(-)-BAY K 8644 Usage And Synthesis |
| Uses | (S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia?in rats. | | General Description | (S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+?channel activator. It is an enantiomer of Bay K 8644. | | Biological Activity | L-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ). | | Biochem/physiol Actions | (S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions. |
| S(-)-BAY K 8644 Preparation Products And Raw materials |
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