ALPHA-HELICAL CRF (9-41)

CAS No.：99658-03-4

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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ALPHA-HELICAL CRF (9-41) Basic information

Product Name:	ALPHA-HELICAL CRF (9-41)
Synonyms:	CORTICOTROPIN RELEASING FACTOR ANTAGONIST;H-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2;ASP-LEU-THR-PHE-HIS-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-ALA-GLU-GLN-ALA-LEU-ASN-ARG-LEU-LEU-GLU-ALA-NH2;ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-MET-LEU-GLU-MET-ALA-LYS-ALA-GLU-GLN-GLU-ALA-GLU-GLN-ALA-ALA-LEU-ASN-ARG-LEU-LEU-LEU-GLU-GLU-ALA-NH2;ALPHA-HELICAL CORTICOTROPIN RELEASING FA CTOR;α-helical corticotropin releasing factor fragment (9-41);ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR (9-41);ALPHA-HELICAL CORTICOTROPIN RELEASING FACTOR FRAGMENT (9-41)
CAS:	99658-03-4
MF:	C22H25IN2O6
MW:	540.34817
EINECS:
Product Categories:	CRF receptor and related
Mol File:	99658-03-4.mol

ALPHA-HELICAL CRF (9-41) Chemical Properties

storage temp.	−20°C
form	powder
color	white

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

ALPHA-HELICAL CRF (9-41) Usage And Synthesis

Biochem/physiol Actions

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

ALPHA-HELICAL CRF (9-41) Preparation Products And Raw materials

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