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| 1,1'-Carbonyldiimidazole Basic information |
| 1,1'-Carbonyldiimidazole Chemical Properties |
| Melting point | 117-122 °C(lit.) | | Boiling point | 288.83°C (rough estimate) | | density | 1.303 g/mL at 25 °C | | vapor pressure | 0.006-0.012Pa at 20-25℃ | | refractive index | n20/D1.434 | | storage temp. | 2-8°C | | solubility | Soluble in dimethylformamide. | | form | Crystalline Powder | | pka | 2.90±0.10(Predicted) | | color | White to light cream | | PH Range | 7.7 at 50 g/l | | PH | 7.7 (50g/l, H2O, 20℃) | | Water Solubility | Insoluble in water | | Sensitive | Moisture Sensitive | | Merck | 14,1819 | | BRN | 6826 | | Stability: | Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water. | | InChIKey | PFKFTWBEEFSNDU-UHFFFAOYSA-N | | CAS DataBase Reference | 530-62-1(CAS DataBase Reference) | | EPA Substance Registry System | 1H-Imidazole, 1,1'-carbonylbis- (530-62-1) |
| 1,1'-Carbonyldiimidazole Usage And Synthesis |
| Chemical Properties | White crystalline powder | | Uses | Used in the synthesis of peptides. Contains up to 10% imidazole. | | Uses | peptide coupling reagent | | Uses | CDI is mainly employed to convert alcohols and amines into carbamates, esters, and ureas. It is also used in the synthesis of peptides and nucleoside triphosphates. | | Uses | 1,1'-Carbonyldiimidazole is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.
| | Uses | Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohols and amines into carbamates, esters, and ureas. It is involved in the preparation of formylized imidazole by reaction with formic acid. Further, it is used in the synthesis of dipolar polyamides compounds. In addition to this, it is considered as an equivalent of phosgene and used to prepare asymmetric bis alkyl carbonate. | | General Description | 1,1′-Carbonyldiimidazole (N,N′-carbonyldiimidazole) is a versatile peptide-forming reagent. | | Purification Methods | Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.] |
| 1,1'-Carbonyldiimidazole Preparation Products And Raw materials |
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