2-(Di-tert-butylphosphino)biphenyl Five Chongqing Chemdad Co. ，Ltd

Product

2-(Di-tert-butylphosphino)biphenyl

CAS No.：224311-51-7

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2-(Di-tert-butylphosphino)biphenyl Basic information

Product Name:	2-(Di-tert-butylphosphino)biphenyl
Synonyms:	(2-biphenyl)di-tert-butylphosphine;(2-BIPHENYLYL)DI-TERT-BUTYLPHOSPHINE;2-(DI-TERT-BUTYLPHOSPHINO)BIPHENYL;2-(DI-T-BUTYLPHOSPHINO)BIPHENYL;BIPHENYL-2-YL-DI-TERT-BUTYL-PHOSPHANE;2-(Di-t-butylphosphino)biphenyl,99%JohnPhos;2-(Di-t-butylphosphine) biphenyl;PHOSPHINE, [1,1''-BIPHENYL]-2-YLBIS(1,1-DIMETHYLETHYL)-
CAS:	224311-51-7
MF:	C20H27P
MW:	298.4
EINECS:	607-074-9
Product Categories:	Achiral Phosphine;Aryl Phosphine;Ligand;organophosphine ligand;Buchwald Ligands Series;Buchwald Ligands&Precatalysts;Benzene derivatives;Phosphines;Phosphine Ligands;Synthetic Organic Chemistry
Mol File:	224311-51-7.mol

2-(Di-tert-butylphosphino)biphenyl Chemical Properties

Melting point	86-88 °C (lit.)
Boiling point	405.5±24.0 °C(Predicted)
density	1 g/cm³
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonic
form	Crystals or Crystalline Powder
color	White
Water Solubility	Insoluble
BRN	8322131
Stability:	Air Sensitive
InChIKey	CNXMDTWQWLGCPE-UHFFFAOYSA-N
CAS DataBase Reference	224311-51-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	36/37/38-22
Safety Statements	36/37/39-26-22
WGK Germany	3
F	10-23
TSCA	No
HazardClass	AIR SENSITIVE
HS Code	29029090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

2-(Di-tert-butylphosphino)biphenyl Usage And Synthesis

Reactions	Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates. Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates. Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides. Effective ligand used in palladium-catalyzed arylation of thiazoles. Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation. Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.
Chemical Properties	white to light yellow crystal powde
Uses	suzuki reaction
Uses	2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions.
General Description	JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.

2-(Di-tert-butylphosphino)biphenyl Preparation Products And Raw materials

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