2-(Di-tert-butylphosphino)biphenyl

CAS No.：224311-51-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-(Di-tert-butylphosphino)biphenyl Basic information

Reactions

Product Name:	2-(Di-tert-butylphosphino)biphenyl
Synonyms:	(2-biphenyl)di-tert-butylphosphine;(2-BIPHENYLYL)DI-TERT-BUTYLPHOSPHINE;2-(DI-TERT-BUTYLPHOSPHINO)BIPHENYL;2-(DI-T-BUTYLPHOSPHINO)BIPHENYL;BIPHENYL-2-YL-DI-TERT-BUTYL-PHOSPHANE;2-(Di-t-butylphosphino)biphenyl,99%JohnPhos;2-(Di-t-butylphosphine) biphenyl;PHOSPHINE, [1,1''-BIPHENYL]-2-YLBIS(1,1-DIMETHYLETHYL)-
CAS:	224311-51-7
MF:	C20H27P
MW:	298.4
EINECS:	607-074-9
Product Categories:	Achiral Phosphine;Aryl Phosphine;Ligand;organophosphine ligand;Buchwald Ligands Series;Buchwald Ligands&Precatalysts;Benzene derivatives;Phosphines;Phosphine Ligands;Synthetic Organic Chemistry
Mol File:	224311-51-7.mol

2-(Di-tert-butylphosphino)biphenyl Chemical Properties

Melting point	86-88 °C (lit.)
Boiling point	405.5±24.0 °C(Predicted)
density	1 g/cm³
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonic
form	Crystals or Crystalline Powder
color	White
Water Solubility	Insoluble
BRN	8322131
Stability:	Air Sensitive
InChIKey	CNXMDTWQWLGCPE-UHFFFAOYSA-N
CAS DataBase Reference	224311-51-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	36/37/38-22
Safety Statements	36/37/39-26-22
WGK Germany	3
F	10-23
TSCA	No
HazardClass	AIR SENSITIVE
HS Code	29029090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

2-(Di-tert-butylphosphino)biphenyl Usage And Synthesis

Reactions	Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates. Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates. Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides. Effective ligand used in palladium-catalyzed arylation of thiazoles. Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation. Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.
Chemical Properties	white to light yellow crystal powde
Uses	suzuki reaction
Uses	2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions.
General Description	JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.

2-(Di-tert-butylphosphino)biphenyl Preparation Products And Raw materials

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