Product

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

CAS No.：1139453-98-7

Other grades of this product :

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Basic information

Product Name:	N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
Synonyms:	Nidanib Impurity 12: N-methyl-2- (4-methylpiperazin-1-yl) -N- (4-nitrophenyl) -acetamide;N-Methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide;N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide;N,4-Dimethyl-N-(4-nitrophenyl)-1-piperazineacetamide;Nintedanib impurity 2/N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide;Nintedanib Intermediate 1;Intedanib Impurity 12;Nintedanib-003
CAS:	1139453-98-7
MF:	C14H20N4O3
MW:	292.33
EINECS:
Product Categories:	Intermediate of BIBF-1120 and PKI587
Mol File:	1139453-98-7.mol

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Chemical Properties

Melting point	94 - 96°C
Boiling point	446.9±40.0 °C(Predicted)
density	1.230
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.43±0.10(Predicted)
form	Solid
color	Pale Yellow to Light Yellow

Safety Information

MSDS Information

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Usage And Synthesis

Uses	N-Methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide is used as a reactant in the synthetic preparation of 6-methoxycarbonyl-substituted indolinones, such as Intedanib (I666650), which is a triple angiokinase inhibitor and antitumor agent.

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide Preparation Products And Raw materials

Raw materials	2-broMo-N-Methyl-N-(4-nitrophenyl)acetaMide-->2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE-->1-Bromo-4-nitrobenzene-->1-Methylpiperazine-->N-Methyl-4-nitroaniline
Preparation Products	(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

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